Did you know: most lubricants (and yes, saliva) can harm sperm motility, exactly the opposite of what you want when youre trying to grow your family. Our Power Play Lube was created to help your Fertility Lubricant for Conception Support Sperm Safe Lube Bird&Be Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Best Fertility Friendly Lubricants When Trying to Get Pregnant AskMen The most pregnancy friendly lubricants are the water based kinds. These lubes are water soluble, which means they dissolve in water. They're safer for you and your baby, typically because they contain fewer chemicals than Do Lubricants Affect Pregnancy Chances? Many couples wonder if lubricants can prevent conception. Oil based lubricants (like Vaseline, coconut oil, creams, lotions) can slow down sperm movement and reduce pregnancy chances.